解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) regulates a battery of antioxidant, detoxification, and cell stress genes. It is activated by oxidative stress and a number of exogenous compounds, one of which is tert-butylhydroquinone (tBHQ), a widely used food preservative. Nrf2 modulates ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.11.006
更新日期:2015-02-01 00:00:00
abstract::The purpose of this study was to determine if vitamin D status before supplementation influences the cytokine response after supplemental vitamin D. Forty-six reportedly healthy adults (mean(SD); age, 32(7) y; body mass index (BMI), 25.3(4.5) kg/m(2); serum 25-hydroxyvitamin D (25(OH)D), 34.8(12.2) ng/mL) were randoml...
journal_title:Cytokine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.cyto.2014.09.012
更新日期:2015-02-01 00:00:00
abstract::Neuropathic pain is a debilitating condition caused by damage to the somatosensory nervous system, such as peripheral nerve injury. The immune system, and in particular the adaptive T cell response, plays a key role in mediating such pain. Regulatory T (Treg) cells are a small subpopulation of inhibitory T cells that ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.10.028
更新日期:2015-02-01 00:00:00
abstract::Dendritic cell-based vaccines are considered as a new and promising immunotherapeutic approach for cancer treatment. However, the choice of optimal protocol of dendritic cell generation in vitro represents the major challenge. Here, we compared phenotype and functional characteristics of human monocyte-derived dendrit...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.07.258
更新日期:2015-01-01 00:00:00
abstract::The immunomodulatory functions of prolactin (PRL) are well recognized. Augmented PRL plasma levels were observed in patients with advanced tuberculosis (TB). Recently, we have reported that LPS and Mycobacterium bovis (M. bovis) induced differential expression of PRL receptor (PRLR) isoforms in THP-1 cells and bovine ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.08.006
更新日期:2015-01-01 00:00:00
abstract::Ocular trauma affects 20% of Americans in their lifetime and can cause permanent visual system damage. We have used a mouse model of ocular trauma (exposure to an air blast from a paintball gun) to examine pathways that trigger the resulting retinal damage and to develop treatment strategies that might ameliorate the ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.07.004
更新日期:2014-12-01 00:00:00
abstract::Elevated levels of the cytokine IL-13 has been found to be associated with autoimmune diseases, including Sjögren's Syndrome. However, whether IL-13 plays a causative role in disease development is not known and cannot be easily studied in humans. Our previous work has shown that levels of IL-13 are elevated in Id3 kn...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.06.009
更新日期:2014-10-01 00:00:00
abstract::Macrophage migration inhibitory factor (MIF) is a molecule with plethora of functions such as regulation of immune response, hormone-like, enzymatic and chaperone-like activity. Further, MIF is a major participant in glucose homeostasis since it is an autocrine stimulator of insulin secretion. MIF absence in male knoc...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.05.013
更新日期:2014-09-01 00:00:00
abstract::The dental pulp space can become infected due to a breach in the surrounding hard tissues. This leads to inflammation of the pulp (pulpitis), soft tissue breakdown, and finally to bone loss around the root apex (apical periodontitis). The succession of the molecular events leading to apical periodontitis is currently ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.05.014
更新日期:2014-09-01 00:00:00
abstract::Interleukin(IL)-2 and IL-7 are cytokines with important functions related to CD4(+) lymphocyte proliferation, differentiation and survival. Depending on doses, they theoretically activate regulatory (Treg) and/or effector T cells (Teff) and thus may be indicated with different therapeutic objectives. In this study we ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.05.021
更新日期:2014-09-01 00:00:00
abstract::To date, the biological activity of granulocyte macrophage-colony stimulating factor (GM-CSF) has been investigated by using mostly Escherichia coli- or yeast cell-derived recombinant human GM-CSF (erhGM-CSF and yrhGM-CSF, respectively). However, Chinese hamster ovary cell-derived recombinant human GM-CSF (crhGM-CSF),...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.03.009
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Among all cytokines involved in the pathogenesis and in the progression of psoriasis, Tumor Necrosis Factor (TNF)-alpha and interleukin (IL)-17 play a pivotal role. OBJECTIVE:The aim of the present study was to mimic a psoriatic microenvironment and to investigate the early effects of TNF-alpha and IL-17 in...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.03.003
更新日期:2014-07-01 00:00:00
abstract::An anti-inflammatory cytokine, interleukin-10 (IL-10) exerts inhibitory effects on vascular inflammation. Chemokines promote vascular inflammation and play a pathogenic role in the development and maintenance of hypertension. However, chemokine CCL5 has down-regulatory effects on angiotensin II (Ang II)-induced hypert...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.02.008
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Estrogen is thought to aid maintenance of insulin sensitivity potentially through modulation of a counter-regulatory mechanism that interferes with the contribution of adaptive and innate immune systems to visceral fat deposition. We evaluated the impact of estrogen on long-term high fat diet (HFD) intake in...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.02.011
更新日期:2014-06-01 00:00:00
abstract::Cytokines are involved in the pathogenesis of community acquired pneumonia (CAP). The aim of this study is to investigate the association of IL6-174 G/C gene polymorphism with CAP in Egyptian children, to assess its effect on CAP outcome and to determine its effect on the serum IL6 levels in these children. IL6-174 G/...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.02.013
更新日期:2014-06-01 00:00:00
abstract::The functions of phagocytic cells against pathogens are initiated by the interaction between membrane receptors and molecular structures which compose the cell wall of these microorganisms. Thus our study aimed to identify the neutrophil receptors involved in the recognition of different strains of Paracoccidioides br...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.02.004
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Secondhand smoke (SHS) exposure is a risk factor of respiratory, cardiovascular and inflammatory diseases, however its association with inflammatory markers among highly SHS exposed adolescents has not yet been explored. METHODS:Participants included in this study were a subset of 68 non-smoking adolescents...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.12.007
更新日期:2014-03-01 00:00:00
abstract::Neutrophil microparticles (NMs) are scarce in the circulation but are highly enriched at sites of inflammation and exert profound effects on immune cells. In the present study, we addressed whether NMs modulate cytokine-producing capacity of natural killer (NK) cells. NMs inhibited the production of IFN-γ and TNF-α bu...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.11.010
更新日期:2014-02-01 00:00:00
abstract::Recently, we reported that extracellular ubiquitin functions as another agonist of CXC chemokine receptor (CXCR)4. Whereas the cognate CXCR4 ligand, stromal cell-derived factor (SDF)-1α, is also a CXCR7 agonist, ubiquitin does not bind to CXCR7. Because both ligands are present in the extracellular environment, co-act...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.12.008
更新日期:2014-02-01 00:00:00
abstract::Previous studies identified the variant IFNG +874A/T (rs2430561) in the first intron of the gene in association with mycobacterial infection, especially tuberculosis and leprosy. The aim of this investigation was to analyze the protective role of the T allele in relation to leprosy using a meta-analysis evaluation. Th...
journal_title:Cytokine
pub_type: 杂志文章,meta分析
doi:10.1016/j.cyto.2013.12.002
更新日期:2014-02-01 00:00:00
abstract::X-linked lymphoproliferative syndrome (XLP) is a rare primary immunodeficiency characterized by increased vulnerability to Epstein-Barr virus infection. XLP type 1 is caused by mutations in SH2D1A, whereas X-linked inhibitor of apoptosis (XIAP) encoded by XIAP/BIRC4 is mutated in XLP type 2. In XIAP deficiency, hemoph...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.09.007
更新日期:2014-01-01 00:00:00
abstract:UNLABELLED:Hyperoxia exposure can inhibit alveolar growth in the neonatal lung through induction of p21/p53 pathways and is a risk factor for the development of bronchopulmonary dysplasia (BPD) in preterm infants. We previously found that activation of nuclear factor erythroid 2 p45-related factor (Nrf2) improved survi...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.09.021
更新日期:2014-01-01 00:00:00
abstract::The transforming growth factor-beta 1 (TGFβ1) and NFκB pathways are important regulators of epidermal homeostasis, inflammatory responses and carcinogenesis. Previous studies have shown extensive crosstalk between these pathways that is cell type and context dependent, but this has not been well-characterized in epide...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.09.004
更新日期:2013-12-01 00:00:00
abstract::An accurate and simultaneous estimate of cellular levels of a large cytokine number is very useful to obtain information about an organ dysfunction leading to cancer because through the understanding of the evolution of cytokine patterns we can recognize and predict the disease progression. Cancer cell lines are commo...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.09.002
更新日期:2013-11-01 00:00:00
abstract::Atherosclerosis is an inflammatory disease of the vasculature regulated by cytokines. Macrophages play a crucial role at all stages of this disease, including regulation of foam cell formation, the inflammatory response and stability of atherosclerotic plaques. For example, matrix metalloproteinases produced by macrop...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.06.315
更新日期:2013-10-01 00:00:00
abstract::Interleukin 17 (IL-17) as one of the pro-inflammatory cytokines is a very important player in the immune response to many pathogens and seems to play a role also in certain chronic and autoimmune diseases. Many studies showing the importance of this cytokine were conducted on murine models and human patients. In recen...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2013.06.002
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Interleukin 17 (IL-17) is induced during the early stages of tuberculosis infection, playing an important role in the defense against mycobacterial infection. To date, only one study performed in Chinese Han population has found an association between IL-17F sequence variants and susceptibility to tuberculos...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.05.022
更新日期:2013-10-01 00:00:00
abstract::Castration-refractory prostate cancer (CRPC) is treated with taxane-based chemotherapy, but eventually becomes drug resistant. It is thus essential to identify novel therapeutic targets for taxane resistance in CRPC patients. We investigated the role of the chemokine (C-C motif) receptor 1 (CCR1) and its ligand, chemo...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.06.313
更新日期:2013-10-01 00:00:00
abstract::Identifying and blocking chemokine inflammatory mediators in pediatric opsoclonus-myoclonus syndrome (OMS) is critical to the treatment of this autoimmune, paraneoplastic, neurological disorder. In a prospective, case-control, clinico-scientific study of children with OMS compared to non-inflammatory neurological cont...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.05.020
更新日期:2013-10-01 00:00:00
abstract:RATIONALE:Sarcoidosis is an idiopathic granulomatous disorder with heterogeneous clinical manifestations and variable prognosis. Monitoring disease activity is important to identify patients requiring treatment. Several cytokines have previously been shown to be elevated in the serum of patients with sarcoidosis and ma...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.07.010
更新日期:2013-10-01 00:00:00
abstract::TNF-related apoptosis inducing ligand (TRAIL) plasma levels was measured in plasma samples obtained 1h (time 1) and 2-3 days (time 2) after delivery in a group of healthy women (n=17) who underwent cesarean delivery, and showed a significantly increase from time 1 (39.3 pg/ml median; 41.2 ± 15.9 mean ± SD) to time 2 (...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.05.005
更新日期:2013-10-01 00:00:00
abstract::The genetic producibilities of T helper type 1 (Th1) and T helper type 2 (Th2) cytokines are associated with the prognosis of autoimmune thyroid diseases (AITDs). Interleukin (IL)-10 is considered to be a Th2 cytokine that can exhibit an anti-inflammatory role. Furthermore, IL-10 may be associated with the development...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.05.014
更新日期:2013-10-01 00:00:00
abstract::During the quarter of a century since TNF was isolated, much knowledge has been gained of the identity of other ligands besides TNF in the TNF cytokine family, and of the proximal signaling molecules that these ligands activate. The numerous laboratories contributing to this advance have approached TNF research from v...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2013.05.027
更新日期:2013-09-01 00:00:00
abstract::The TNF-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) superfamily that has been recognized for its specific pro-apoptotic effect on cancer cells and has been therefore proposed as a treatment in cancer. Studies on animal models have shown that TRAIL could also have a benefici...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2013.04.011
更新日期:2013-08-01 00:00:00
abstract::This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. Image duplication has been observed within Figure 1g-h. The corresponding author has been a...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.04.009
更新日期:2013-07-01 00:00:00
abstract:PURPOSE:Tumor necrosis factor (TNFα) is a proinflammatory cytokine and has been a target for intervention in human sepsis. However, inhibition of TNF-α with a high dose of a TNF-receptor fusion protein in patients with septic shock worsened patient survival. This study was designed to investigate whether blocking TNF-α...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.04.002
更新日期:2013-07-01 00:00:00
abstract::IL-12p70 is a proinflammatory cytokine secreted by dendritic cells, monocytes and macrophages. It plays a crucial role in cell-mediated immunity by inducing proliferation of T cell and natural killer cells, and enhancing their cytotoxic activity. In adaptive immune response, it acts on naive T cells to differentiate i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.03.021
更新日期:2013-06-01 00:00:00
abstract::Large amounts of anti-inflammatory mediators, such as interleukin (IL)-10, are produced and found early in the course of sepsis. We explore the role of IL-10 on neutrophil (PMN) activation/function using an in vitro model. Isolated human PMN were pre-incubated with lipopolysaccharide (LPS) and/or IL-10 for 18h. Subseq...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.03.025
更新日期:2013-06-01 00:00:00
abstract::Interleukin-21 (IL-21) is overproduced in human intestines affected by inflammatory bowel disease (IBD) and in the gut of mice with DSS-induced colitis. IL-21-deficient mice are largely protected against DSS-induced colitis, indicating that IL-21 plays a key role in the development of IBD. We previously identified a n...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.03.006
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Hypertension is one of the most prominent risk factors for coronary artery disease (CAD). Treatment of hypertension is therefore important for reducing cardiovascular events and the progression of atherosclerosis. Several treatment strategies are common in clinical practice for example the use of ACE-blocker...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.02.001
更新日期:2013-05-01 00:00:00